Endocrine Abstracts

Background: Sleep loss in the early morning has been shown to reduce secretory activity of the pituitary–gonadal axis in men, but the determinants of this effect are unknown.Objective: To assess the effects of sleep restriction on serum concentrations of LH, testosterone , and prolactin (PRL).Methods: Fifteen young, healthy men were examined in a condition of sleep time restriction to 0245–0700 h for two consecutive night...

Cushing’s disease is caused by ACTH-secreting pituitary adenomas. Gold standard therapy is the resection of the adenoma by transsphenoidal surgery with high cure rates even in cases of negative MR imaging. Surgical failure despite clear endocrinological test results is possible and mostly explained by hidden minute adenomas within the gland.We report on a 50-year-old woman suffering from ACTH-dependent Cushing’s syndrome. Endocrinological work-...